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Think about alternant therapies that are not reasonable CYP3A inducers in the course of procedure with mitapivat. If struggling to stay away from coadministration, keep an eye on Hb and titrate further than 50 mg BID, if needed, but never exceed mitapivat dose of one hundred mg BID. .Following halting a CYP3A4 inducer, given that the effects of the